Phenylpropanoids and polyketides
TARGETMOL CHEMICALS INC Tacrolimus monohydrate 100MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo. Purity 99.2%
Medchemexpress LLC 2-Propenoic acid,3-(3-hydroxyphenyl)- | 588-30-7 | 100.0% | 164.16 | 100 MG
m-Coumaric acid is a polyphenol metabolite derived from caffeic acid, produced by gut microflora, and its concentration in human biofluids depends on diet. It is a BBB-penetrant metabolite of chlorogenic acid. In vitro, m-Coumaric acid stimulates cerebral nerves and can evoke neurite outgrowth in hippocampal neuronal cells, promoting neuronal differentiation.
- Increases spontaneous locomotor activity in mice
- Inhibits L-dopa oxidation by epidermis tyrosinase
- Attenuates non-catalytic protein glycosylation in retinas of diabetic rats
- Suitable for research and analytical applications
Medchemexpress LLC CE(20:5(5Z,8Z,11Z,14Z,17Z) | 74892-97-0 | 99.9% | 671.09 | 1 MG
CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite intended for research use only and not for patient use. It presents as a colorless to light yellow liquid.
- Endogenous metabolite
- Colorless to light yellow liquid
- Chemical formula C47H74O2
- Classified under steroids and natural products
- Recommended shipping at room temperature in continental US
- Solution storage at -20°C for 2 years
Cayman Chemical NIcotIflorIn 10mg
A flavonoid; scavenges DPPH and ABTS radicals (EC50s = 0.52 and 0.48 mg/ml, respectively) in cell-free assays; prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in isolated rat mesencephalic neurons at 1 µM; decreases infarct size by 24.5, 45.8, and 63.2% at 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient MCAO
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 100mg
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Selleck Chemical LLC 4-Hydroxycyclohexanecarboxylic
trans-4-Hydroxycyclohexanecarboxylic acid is used as an organic intermediate
eMolecules 4-(4-Trifluoromethylphenyl)phenol | 10355-13-2 | MFCD06802299 | 1g
Combi-Blocks | 4-(4-Trifluoromethylphenyl)phenol | 1g | 117578490 | YA-1773 | 98.000 | 10355-13-2 | MFCD06802299 | 238.209 | C13H9F3O
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Medchemexpress LLC Dihydrochalcone 25g | 1083-30-3 | 210.27 g/mol | C15H14O | 25 G
Dihydrochalcone (CAS 1083-30-3) is a small-molecule research reagent supplied as a high-purity solid for in vitro and analytical applications.
- High purity ≥98%.
- Molecular formula C15H14O.
- Molecular weight 210.27 g/mol.
- Suitable for in vitro biochemical assays and as an analytical reference.
- Available in a 25 G pack for laboratory use.
Medchemexpress LLC Phenyl benzoate | 93-99-2 | 99.9% | 198.22 | 10 G
Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid. It acts as a chloride transport blocker, inhibiting Cl--dependent Glu accumulation into vesicles, and can also be used as a preservative in cosmetic products.
- Benzoate ester derived from phenol and benzoic acid
- Acts as a chloride transport blocker
- Inhibits Cl--dependent Glu accumulation
- Can be used as a preservative in cosmetic products
Selleck Chemical LLC 3-Hydroxycinnamic acid
3-hydroxycinnamic acid (meta-Coumaric acid m-Coumaric acid m-Coumarate) is an aromatic acid that can be found in vinegar
Apexbio Technology LLC Glycoprotein B (485-492) 1mg
Glycoprotein B 485-492 is a viral glycoprotein-derived peptide fragment from herpes simplex virus (HSV) It is designed to facilitate virus-cell membrane fusion by interacting with cellular membranes thereby promoting HSV entry into host cells Glycoprotein B 485-492 exerts its biological activity primarily through its role as part of the viral fusion machinery in conjunction with glycoproteins H and L Based on these properties Glycoprotein B 485-492 holds research potential in investigating HSV fusion mechanisms antiviral development and antigen-antibody interaction studies in viral entry
